Justin Bieber has lyme disease and he announced it to the world via his Instagram see below:

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"While a lot of people kept saying justin Bieber looks like shit, on meth etc. they failed to realize I've been recently diagnosed with Lyme disease, not only that but had a serious case of chronic mono which affected my, skin, brain function, energy, and overall health. These things will be explained further in a docu series I'm putting on YouTube shortly.. you can learn all that I've been battling and OVERCOMING!! It's been a rough couple years but getting the right treatment that will help treat this so far incurable disease and I will be back and better than ever NO CAP"

What is Lyme disease? Here is how the CDC describes it:
Lyme disease is the most common vector-borne disease in the United States. Lyme disease is caused by the bacterium Borrelia burgdorferi and rarely, Borrelia mayonii. It is transmitted to humans through the bite of infected blacklegged ticks. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks.  Laboratory testing is helpful if used correctly and performed with validated methods. Most cases of Lyme disease can be treated successfully with a few weeks of antibiotics. Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat. The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.
The good news is that you can hear it straight from Justin in his upcoming Docu series on YouTube. :)